Prostaglandin E synthase

By Targets:	NO Synthase (2) PGE synthase (11) Prostaglandin Receptor (1) COX (1) Lipoxygenase (2) NF-κB (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (12) Neurological Disease (1)

Targets Recommended: PGE synthase Prostaglandin Receptor Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147416

Vipoglanstat BI 1029539; GS-248; OX-MPI	PGE synthase	Infection
Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .

HY-139589

Zaloglanstat ISC-27864; GRC-27864	PGE synthase	Neurological Disease Inflammation/Immunology
Zaloglanstat (ISC-27864) is the inhibitor of the *microsomal prostaglandin* E synthase-1 (mPGES-1)**, and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc .

HY-125415

PF-4693627	PGE synthase	Inflammation/Immunology
PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .

HY-156612

Friluglanstat

PGE synthase Inflammation/Immunology

Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity .
HY-106119

Camonagrel

Prostaglandin Receptor Infection

Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. Camonagrel is a potent thromboxane synthase inhibitor .

Friluglanstat	PGE synthase	Inflammation/Immunology
Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity .

Camonagrel	Prostaglandin Receptor	Infection
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. Camonagrel is a potent thromboxane synthase inhibitor .

HY-19622

PF-9184	PGE synthase	Inflammation/Immunology
PF-9184 is a potent and highly selective inhibitor of human *microsomal prostaglandin* E synthase-1 (mPGES-1), with an IC₅₀** of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE₂ synthesis in vitro .

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-122178

5-trans U-44069	PGE synthase	Cardiovascular Disease
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits **prostaglandin E2 synthase** activity .

HY-100864

mPGES1-IN-3	PGE synthase	Inflammation/Immunology
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC₅₀: 8 nM), cell (A549 IC₅₀: 16.24 nM) and human whole blood potency (IC₅₀: 249.9 nM) .

HY-N9814

Shanciol B	NO Synthase	Inflammation/Immunology
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-126898

5-LO/mPGES1-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells .

HY-N6966

Ethyl Caffeate	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-N6966A

Ethyl trans-caffeate	Others	Inflammation/Immunology
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-N8936

Narchinol B	Others	Inflammation/Immunology
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6966

Ethyl Caffeate	Structural Classification Classification of Application Fields Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Inflammation/Immunology Disease Research Fields Cancer	NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-N6966A

Ethyl trans-caffeate	Source classification Lactuca perennis Plants Compositae	Others
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-N9814

Shanciol B	Pholidota imbricata Hook. Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	NO Synthase
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-N8936

Narchinol B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

Cat. No.	Compare	Product Name	Species	Source

HY-P702418

	PTGES Protein, Mouse (Cell-Free, His, SUMO) Microsomal Prostaglandin E synthase 1 mPGES-1; Pges	Mouse	E. coli Cell-free
	PTGES proteins act as terminal enzymes in COX-2-mediated PGE2 biosynthesis and regulate inflammation, fever, and pain. In response to inflammatory stimuli, PTGES catalyzes the glutathione-dependent redox of PGH2 to PGE2. PTGES Protein, Mouse (Cell-Free, His, SUMO) is the recombinant mouse-derived PTGES protein, expressed by E. coli Cell-free , with N-10*His, N-SUMO labeled tag. The total length of PTGES Protein, Mouse (Cell-Free, His, SUMO) is 153 a.a., with molecular weight of 35.8 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81182

PTGES2 Antibody C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated Prostaglandin E synthase 2; MGC11289; Microsomal Prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PGES2_MOUSE.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow)
PTGES2 Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-PTGES2 polyclonal antibody. PTGES2 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow background without labeling.

HY-P83386

p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic Prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P81996

Prostaglandin E Synthase Antibody (YA1741)

PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
WB Human, Mouse, Rat

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